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Rayna Bryaskova. Journal of gastrointestinal and liver diseases: JGLD. Ruxandra Moroti. Sampath Jayaweera. Daniela Iova. Thomas Holland. Marwa Elalfy. Irja Lutsar. Jan Pryor. Ali Rabaan. Editor iajps. Amitis Ramezani. Adina Popa. Grace Antonette Pati. Adillina Taufikarani. Log in with Facebook Log in with Google.<\/p>\n

Remember me on this computer. Enter the email address you signed up with and we’ll email you a reset link. Need an account? Click here to sign up. Download Free PDF. Investigation of Toxoplasma gondii in shellfish from Adriatic Sea, Italy.<\/p>\n

Silva Seraceni. Abstract Objectives: Toxoplasma gondii infection in transplant recipients can lead to toxoplasmosis, which in some cases may have a rapid disease course or to be fatal.<\/p>\n

Related Papers. Interdisciplinary perspectives on infectious diseases Glycopeptide resistance in gram-positive cocci: a review. Asian Pacific Journal of Tropical Disease The bad, the ugly and the demon: A tale of extensively drug-resistant, extended-spectrum beta-lactamase- and metallo-beta-lactamase-producing superbugs associated with nosocomial pneumonia. Antimicrobial susceptibility, virulence factors and biofilm formation among Staphylococcus aureus isolates from hospital infections in Kerman, Iran.<\/p>\n

European Respiratory Journal Guidelines for the management of adult lower respiratory tract infections. Burghoffer, J. Objectives: Recent studies have suggested that members of the genus Of 50 S. The aim of the study was to further investigate Conclusion: Presence of FnBPs in our study population was lower this question and to extend it the closely related Campylobacter genus. Stools were also cultured for 10 days on Skirrow-supplemented blood agar plates in a microaerophilic R Effectiveness of albendazol against viability of Entamoeba atmosphere.<\/p>\n

The A. The H. A study was negative. The C. Culture yielded only Material and Methods: All experimental animal models mice and two C. Thus in addition to the controls without drugs. Stool specimens of each group Helicobacteriaceae may have a pathogenic role in the development of were examined microspically for viable trophozoites, and the number IBD. Statistical methods used was student t-test. Results: The results showed infection of E.<\/p>\n

Yapar, V. Trphozoites of E. Nasal carriage rates for S. Methods: Fifty S. Specimens in vivo studies were inoculated on mannitol salt agar plates and all colonies surrounded L. Methicillin susceptibility tests of all strains effects for treating Toxoplasma infection, this study was conducted to were performed by disk diffusion test using 30 mcg cefoxitin disks investigate the effect of AS on Toxoplasma gondii T. The assessment H. In the in vivo study, Swiss albino mice were infected intraperitoneally with tachyzoites of RH strain of T.<\/p>\n

Parasite burden, viability, infectivity tigecycline, rifampicin and combined regimens and ultrastructure changes of tachyzoites harvested from the peritoneal J. Cheong, Y. Jo, W. Choi, M. Kim, J. Heo, cavities of infected treated mice, in comparison with that of infected J. Noh, W. Kim Seoul, KR non-treated control animals, were also studied.<\/p>\n

In addition AS as compared with the untreated controls. Regarding the in vivo to the diverse resistance mechanisms, some A. There was also effectiveness. Regarding VIM-2 strains, neither imipenem, of T. In comparison, tigecyclin 0. Likewise, both imipenem and L. Grande, M. Di Giulio, S.<\/p>\n

Di Bartolomeo, E. Di Campli colistin were also effective at the reduced concentrations when those were Chieti, IT combined with rifampicin. This cellular response strains. Kratzer, A. Lassnigg, W. Graninger, E. Presterl the formation and in the detachment of the H. Bacterial cultures grown on polystyrene surfaces were exposed at Objectives: Candida species are emerging as important pathogens. In non invasive were expressed. Resistance rates among commonly used antimicrobials and CFD were: ampicillin Lopes, I.<\/p>\n

Machado, M. Vieira, M. For 1 NS isolate there was no killing effect. In this study, we examined the effect of adaptation of P. Zorpas, G. Charkoftaki, E. Bacterial adaptation was attained N. Kostomitsopoulos, A. Skoutelis, H. Archontaki, G. Valsami Athens, by exposing P. The results show that adapted P. For both strains, the pre-conditioning from minocycline.<\/p>\n

The higher and anaerobic bacteria including multidrug resistant Gram positive and adhesion was observed with the adapted bacteria onto the conditioned Gram negative pathogens. PET coupons. These results highlight that the extent of adhesion is Trigecyclin was found to exhibit large volume of distribution in healthy greater the higher are the stress factors.<\/p>\n

The strength of adhesion is also humans, indicating extensive tissue distribution and half-life elimination higher in the case of adapted bacteria since detachment only occurs with of 37 to 67 hours. Nevertheless, BZK attack causes loss of viability of the cells that Objectives: To measure T accumulation to body tissues at steady state remained adhered to the surfaces, this loss being more notorious in the in order to construct a full body physiological based PK model and to case of non adapted cells adhered in the conditioned surfaces.<\/p>\n

After a on the adhesion surfaces did not impair the bacterial adhesion capacity loading IV dose of 75 mg T in 15 min, animals received It can also be concluded during a 2.<\/p>\n

Blood sample measurement at 60, 45, 30 and a common antimicrobial agent increased its adherence ability and 15 min prior and immediately after the end of the 2. At the end of the 2. Tissue samples were taken to determine the eradication of pathogenic bacteria with increased virulence from drug accumulation.<\/p>\n

Blood samples were centrifuged at rpm for equipment and surfaces in the medical arenas. Poulakou, M. Souli, N. Lambri, Z. Chryssouli, Gallbladder Kanellakopoulou, H. Giamarellou Athens, GR Bile In view of Results: The result are presented in the table. S 19th ECCMID, Abstracts accepted for publication only Conclusion: Results show that in rabbits T accumulates to well perfused fruiting body of macro fungi particularly to the members of Agaricales, tissues such as kidneys, liver, spleen, muscle and testicular tissue.<\/p>\n

Due edible as well as highly poisonous species. Medicinal mushrooms have to its hydrophilic nature tigecycline concentration in fat tissues is low been used in folk medicine throughout the world since the ancient times.<\/p>\n

The present investigation aims to study the antimicrobial activity of medicinal mushroom namely Ganoderma Reishi. Waters, H. Sader, G. Moet North Liberty, US method and determination minimum inhibitory concentration by standard tube agglutination. However, Assay susceptibility tests employed the CLSI M7-A7 method with 20 further separation and fraction of polysaccharide fractions need to be incremental dilutions steps between 0.<\/p>\n

Only MIC assays are presented. Doustdar, P. Farnia, A. Selection of generic products inhA regulatory region and oxyR-ahpC intergenic region. Results: The RL polymorphism in katG gene was detected with high frequency in both Isoniazid resistant and sensitive isolates. The ahpC 46A was the most common mutation in the oxyR-ahpC intergenic region which was present in R Antimicrobial effect of polysaccharide extract of Ganoderma on some pathogen microorganisms R The accumulation of resistance mutations in Mycobacterium A.<\/p>\n

Jahedi, M. Naghmachi Yasuj, IR tuberculosis in vitro I. Bergval, A. Schuitema, P. Klatser, R. Due to emergence of resistance to antibiotics amongst microorganisms, investigations for Objectives: In Mycobacterium tuberculosis MTB , antibiotic resistance novel antimicrobial agents have always been one of the major pre- is almost exclusively established by point mutations. Multidrug- occupations of the medical society. Although the acquisition of resistance mutations is random, the genetic routes leading to the development of successful and virulent R High prevalence of mefE gene among macrolide-resistant Streptococcus pneumoniae isolates in Istanbul multi drug-resistant bacteria may be quite constrained Weinreich DM et al.<\/p>\n

Aksu, U. Over-Hasdemir Istanbul, TR of the strain in question. Macrolide MDR strains. Drug-resistant mutants were macrolides, lincosamids, or streptogramin B. Methods: The prevalence of erythromycine resistance have been Results: Different clades have a preference for different distributions determined by disk diffusion method in 91 S.<\/p>\n

Most found to be resistant to erythromycin in disk diffusion test. The presence of mef genes and ermB genes were analysed resistance. Our results for the erythromycin resistant isolates were in cMLSB phenotype and 2 were in variation in distribution of spontaneous rpoB mutations between different M phenotype Table 1.<\/p>\n

Phenotypic and genotypic test results in erythromycin resistant S. Clin Microbiol These results suggest the sequence Resistance phenotype No.<\/p>\n

Bifidobacterium strains B. Sulaiman, F. Mustafa, Z. Sekawi, H. Ghazali, range. Of the 26 erytromycin resistant strains, 14 Hussin, B. Kabeir, A. Four different levels of pH were used 5. Adhesion was S. The evaluation ability of B. Nilgate, Y. Poovorawan Bangkok, TH for both strains were at pH level 5. The ability to inhibit the adhesion or competitive increasing problem worldwide. Other mechanisms Conclusion: Our results indicate that the ability to adhere and inhibit of resistance include mutations in 23S rRNA and ribosomal proteins L4 adhesion of pathogens can be used for preliminary screening in order and L The aim of this study was to investigate the prevalence and to identify potentially probiotic bacteria suitable for human or animal molecular mechanisms of macrolide resistance in invasive S.<\/p>\n

Methods: A total of invasive S. Mutations in the genes encoding domain V of the four carbapenems and metronidazole. University Hospital. The specimens were collected, transported, and Results: Of the invasive S. Of the 36 erythromycin- 5-nitroimidazole were performed according to recommendations of CLSI resistant isolates, 12 There were no resistant strains against metronidazole. Metronidazole resistance genes were not detected among all strains. Only B. Four strains of B. Rachdi, M.<\/p>\n

Hraoui, M. Saidani, I. Boutiba-Ben Boubaker, S. For the present, it looks like there was no risk for metronidazole resistance. A to be important to monitor B. MICs were determined by E-test for erythromycin, clarithromycin, clindamycin, Resistance surveillance azithromycin, quinupristin-dalfopristin and linezolid. Most erythromycin resistant isolates were recovered A. Merentes, J. Delgado, R. Linezolid and Venezuela has a national surveillance program for bacterial resistance quinupristin-dalfopristin showed excellent activity MIC 0.<\/p>\n

We present here the historic evolution of S. Neither resistance to b-lactam nor high level in our country. All strains categorised as M phenotype carried the mefA system. The Whonet software was used for prospective data entry and gene in 7. For data management the Epi Info 3. MLSB constitutive phenotype conferring cross- computing were used. Dengel Uzunkaya, N. Karavus, G. Soyletir of MRSA, since then a high increased have seen.<\/p>\n

The reasons for these Istanbul, TR increase are no clear. The presence of Chilean clone has been observed. Background: Bacteroides fragilis group BFG is the most commonly encountered bacteria from anaerobic infections and more resistant to R Vascular catheter infection pattern. A temporal surveillance study of consecutive episodes in a tertiary-care hospital antmicrobial agents than the other anaerobes. However carbapenems and nitroimidazoles are the most useful antibiotics against Bacteroides, R.<\/p>\n

Nanetti Bologna, IT resistant isolates have been reported. R Ten-year survey of co-trimoxazole and quinolone resistance in Escherichia coli causing urinary tract infections Results: The trend of CVC infections monitored among our inpatients moderately varied during the observation period cases in January- V.<\/p>\n

Xanthaki, A. Tsiringa, G. Sarantopoulos, M. Epitropaki, M. Among the most frequent organisms, Staphylococcus epidermidis accounted for the majority of Objectives: During the recent years, the treatment of choice for isolates cases: Aim of this study was to determine the change in Enterococcus faecalis 5.<\/p>\n

Classic microbiological , and Enterobacter cloacae from 2. Antibiotic susceptibility was tested by the Kirby-Bauer Gram-negative organisms. Although the major causative agents of to Conclusion: The co-trimoxazole and quinolone resistance of Escherichia R Surveillance of antimicrobial resistance and serotype coli in urinary tract infections was highly increased during the last ten epidemiology of Streptococcus pneumoniae in Crete, Greece years, not only in hospitalised but also in community patients.<\/p>\n

Georgiladakis, Z. Gitti, E. Nioti, G. Samonis therapies, should be based on antimicrobial resistance surveillance Heraklion, GR studies. Wenger, G. Vallet, J. Bille, G. Zanetti Methods: A total of clinical isolates of Streptococcus pneumoniae Lausanne, CH collected over a 7-year period, were studied.<\/p>\n

Antimicrobial susceptibility testing was performed by the E-test method and the results were inter- Objectives: Empirical antibacterial therapy in hospitals is usually preted following CLSI guidelines.<\/p>\n

Hospital-wide data were compared with Results: Of the isolates tested, 82 When compared to hospital-wide Conclusion: The results of the present study indicate that continuous antibiograms, susceptibility rates were lower in ICU and surgical units for surveillance remains important for guiding empirical antibiotic treat- E.<\/p>\n

Important differences were also observed between units for P. Distinction according to the type of sample blood vs any other site also did not show relevant differences. Hospital-wide options. Hoeck, B. Grabein, H. Just, I. Schwede, B. Copy strains are excluded. Quality control is mandatory. Data are presented V. Altouvas, A. Giannouli, O. Zarkotou, E. Sotiropoulou, in the table. Kopsari, K. Digalaki Athens, GR regarded as obsolete and was not tested or documented.<\/p>\n

The isolates were Objectives: Urinary tract infections UTI remain the most frequent from all specimen types. Analysing the data by specimen types, urine, infections diagnosed in outpatients as well as in hospitalised patients. According to our data all tested aminoglycosides are still appro- pneumoniae and Proteus mirabilis among urinary isolates during priate drugs.<\/p>\n

The same holds true for aztreonam, cefepime, ceftazidime, the last three years. Amoxicillin should not be used also studied. A remarkable Cefazolin R Regarding E. A more than 5-fold increase was Cefuroxime Resistance rates are presented in detail in the table.<\/p>\n

Lebessi, E. Voulgari, E. Koemtzidou, October Kourakis, A. Tsakris Athens, GR Further work is required to investigate the clinical impact of the emergence of increased mupirocin resistance. Scotland is currently Objectives: Isolation of metallo-b-lactamase MBL -producing Gram- conducting pilot studies into the viability of universally screening negative bacteria represents a serious health care problem.<\/p>\n

Recently, patients for the presence of nasal MRSA upon admission. We present a case of MBL- producing E. The neonate was not treated with antibiotics and the mother had no exposure to antibiotics during pregnancy. Surveillance swabs were taken from the rectum upon admission and cultured in selective medium. Figure 1. MRSA mupirocin bacteraemic isolates to Results: A strain of E. Etest-MBL was positive, indicating production of F. Galani, K. Orlandou, F. Kontopidou, H.<\/p>\n

Giamarellou MBL. The neonate was discharged two days after the admission in good condition. Such a study by antimicrobial agents. Methods: A. Clinical samples were: bronchial secretions A. Wilson, S. Cairns Glasgow, UK It is used routinely for the elimination of instructions.<\/p>\n

CLSI interpretative criteria and guidelines were used. This sulfamethoxazole Among MRSA isolates. Out of meropenem Methods: Scotland participates in the European Antimicrobial Resis- resistant strains 22 Validated data collected over a two year period will be analysed for the Conclusion: Colistin remains active to the majority of A.<\/p>\n

Further studies are needed to isolates resistant to mupirocin within the time period January to establish the extend to which tigecycline is useful in colistin resistant October Plasmid mediated CMY ampC was detected in all isolates.<\/p>\n

CTX-M found is plasmid mediated and, therefore, represents a V. The majority of these isolates correspond to multidrug resistant producers. The aim of this study was to investigate the presence of the genetic elements, the class 1 integrons as well as of R Clones, antibiotypes and virulence genotypes of group C SGI 1 in the resistant and MDR S. Typhimurium DT and U strains. Bexiga, S. Nunes, L. Cavaco, C. Vilela, were included in this study. The strains were tested for susceptibility to I.<\/p>\n

Santos-Sanches Caparica, Lisbon, PT eleven antibiotics by the disk agar diffusion method on Mueller-Hinton Objectives: To determine the clonality, resistance to macrolides, agar plates.<\/p>\n

This same multidrug resistance was from bovine mastitis milk samples collected at Portuguese herds also expressed by the 14 strains of U phagetype. The dominant during \u2014 Among sequencing of the 16S rDNA gene. Antimicrobial resistance 1. Part of the isolates Republic under the project Molecular analysis of antibiotic resistance Among all isolates, the following associations of virulence genes were of nontyphoid salmonella serovars. Phage lysates were obtained from part of the putative lysogenic cultures.<\/p>\n

R Ocurrence of blaCTX-M gene in multidrug-resistant Conclusion: These results suggest an environmental source rather than Citrobacter freundii contagious origin of bovine GCS causing mastitis in Portuguese farms. Paradela, J. Velez, E. Ramalheira, T. Walsh, S. PCR, nucleotide sequencing and sequence G. Nistor, A. Bancescu, M. Andrei, S. Barbuceanu, analysis was employed to detect b-lactamase encoding genes.<\/p>\n

However, these streptococci are often involved in the aetiology of different pyogenic infections. The aim of the present R In vitro activity of tigecycline versus imipenem and versus vancomycin and linezolid against clinical study was to investigate the susceptibility of anginosus streptococci isolates of ESBL-producing E.<\/p>\n

Haefner, S. Lemmen Aachen, DE tract infections mostly oral abscesses and sinusitis. The aim of this study was to compare the tests. The investigation of the susceptibility of the isolates to: local in vitro activity of Tigecycline with Imipenem against ESBL- penicillin G, amoxicillin, erythromycin, clindamycin, chloramphenicol producing Enterobacteriaceae and with Vancomycin and Linezolid and tetracycline was performed by the Etest AB Biodisk, Solna, against Methicillin resistant S.<\/p>\n

The phenotype of erythromycin resistance was detected using Methods: clinical isolates 70 E. The MICs values varied between: 0. Reduced susceptibility to b-lactam expert system BD, Germany was applied, MIC testing was performed antibiotics was found among the strains belonging to S.<\/p>\n

Almost half of the total number of the isolates were resistant to tetracycline. Conclusions: The results indicated that the susceptibility of the oral streptococci isolates of clinical importance should be periodically tested, mainly to the widely-used antibiotics. Clindamycin was fully active as chloramphenicol and might represent a therapeutical alternative for patients allergic to b-lactam antibiotics, while tetracycline is not recommended in infections in which oral streptococci are involved.<\/p>\n

R Daptomycin susceptibility in methicillin-resistant Staphy- lococcus aureus strains isolated from paediatric patients R. Castagnola Genoa, IT Objective: Daptomycin is a cyclic lipopeptide antibiotic that is rapidly bactericidal in vitro against a broad spectrum of Gram-positive bacteria.<\/p>\n

MICs of tigecycline, vancomycin and linezolid against MRSA Its mechanism of action involves calcium-dependent binding to the strains. Resistance is rare. The aim of our study is the evaluation of daptomycin susceptibility in MRSA strains isolated in paediatric patients. Methods: MRSA strains isolated from 74 paediatric patients, between and , were studied.<\/p>\n

Of all this strains None of this strains were vancomycin and linezolide resistant. The minimum inhibitory concentration MIC of daptomycin were determined by using E test. Moreover we studied the eventual slime production using Congo red agar.<\/p>\n

Result: All strains of staphylococci were susceptible to daptomycin and MICs values were between 0. None of 74 MRSA strains were slime producers. Conclusion: The increasing prevalence of Methicillin-Resistant Staphy- lococcus aureus requires the need to search for more effective agents.<\/p>\n

Vancomycin remains the reference standard for the treatment of systemic infection caused by MRSA. However the need for alternative therapies MIC distribution of tigecycline and imipenem against E. Klebsiella sp. Results: The tested strains presented different behaviours in their All MRSA strains were sensitive against the tested antibiotics, thus interaction with cellular and inert substrata in the presence of antibiotics Tigecycline can be used for the indications studied and recommended.<\/p>\n

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Neurontin Tremors Propranolol Toradol Ototoxic. They infiltrate crowd compress and starve out normal tissues. There is a strong association between cigarette smoking and emphysema.. Duration of HRT use was associated with more gentle slopes of decline in episodic memory visuospatial memory and perceptual speed the authors note. A common protocol uses minute stages at set speeds and elevations of a treadmill. QuiCk Hit Massive hemoptysis Defined as more than mL of blood in hours The most common causes are bronchiectasis and bleeding diathesis.<\/p>\n

CT or MRIhelpful if the sacroiliac or facet joints are involvedGeneral characteristicsIndeed he went much further decreeing in that cells besides being the fundamental units of life were the only way that life maintained itself. E YAsupportive psychotherapy Offering encouragement support and hope to patients facing difcult life transitions and events.<\/p>\n

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The acetabulum was named because of its resemblance to a rounded cup the Romans used for vinegar acetumWhich enzymes are used depends on what kind of food you ate and how much you consumed. When right ventricular failure occurs the corresponding signs and symptoms appear JVD hepatomegaly ascites peripheral edema. QT intervalthe normal QT interval should be less than half of the RR intervalmalignant melanoma Cancerous growth composed of melanocytes. This is the diastolic blood pressure pressure in the artery when the ventricles relax and the heart lls receiving blood from the venae cavae and pulmonary veins.<\/p>\n

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This is done the day before the procedure to help the cervix dilate slowly. Thirddegree heart block is always an indication for permanent pacemaker placement. Tests to diagnose biliary atresia include Abdominal xray Abdominal ultrasound Blood tests to check total and direct bilirubin levels Hepatobiliary iminodiacetic acid HIDA scan also called cholescintigraphy to help determine whether the bile ducts and gallbladder are working properly Liver biopsy to determine the severity of cirrhosis or to rule out other causes of jaundice Xray of the bile ducts cholangiogram Treatment An operation called the Kasai procedure is done to connect the liver to the small intestine going around the abnormal ducts.<\/p>\n

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British Medical Journal. Robust forecasting with exponential and Holt\u2014Winters smoothing. Journal of Forecasting. Gardner Jr ES. Exponential smoothing: The state of the art\u2014Part II. International Journal of Forecasting. Introduction: Continuous monitoring of the safety profile of drugs is one of the critical processes of pharmacovigilance.<\/p>\n

As medical literature might be valuable source of safety data, especially for rare, unlisted, serious cases, all MAHs are obliged to medical literature monitoring MLM in all marketing countries [1]. This approach can be changed through modern automation techniques. Objective: To develop and test a tool for automated monitoring of local literature and enhance drug safety data identification.<\/p>\n

Methods: Modern programming approaches were used to create PV platform, intended for automated literature screening. GAMP 5 recommendations were used to prove the validation status.<\/p>\n

Results: We developed a tool\u2014DrugCard PV platform which screens local medical sources for updates on a weekly basis. Till May we added around local journals originated from 10 countries that cover different therapeutic areas. Our tool automatically searches for defined keywords drug trade names, active substances in published articles.<\/p>\n

Different file formats can be screened including text, pdfs, images etc. In case a new issue of a journal is published\u2014a PV specialist will receive an email notification. The mandatory features of a validated computerized system, like audit trail, logs, reports are also present here. Instead of manual reading of the whole journal issue the user only should read a separate article, analyze whether there is a valuable safety data and label it depending on the content.<\/p>\n

PV specialists may work together inside the platform and provide a quality check for labeled articles. Our pilot study of how a new tool may improve the efficiency revealed interesting results.<\/p>\n

Despite the dramatically decreased amount of time needed, the number of identified ICRSs from literature increased. During the abovementioned pilot study of automated local literature monitoring lasting 2 months, 31 safety cases were identified valid and non-valid ICSRs. This is much more than usual rate of safety cases finding.<\/p>\n

It offers increasing efficiency in safety information identification with less time spent on routine activities. Certificate of copyright in Ukraine. Hyperacute toxicity is a recent newly described entity, albeit incompletely characterized [3]. We selected reports with available information to calculate a plausible time-to-onset. Events of interest were classified into fulminant within 7 days and hyper-acute cases within 21 days, i.<\/p>\n

Cases were described in terms of demographic and clinical features: age, gender, anticancer regimen combination vs monotherapy , therapeutic indications, seriousness hospitalization , case fatality rate CFR, namely the proportion of cases where death was reported as outcome , co-reported symptoms, co-reported irAEs.<\/p>\n

The Immune-Adversome was estimated considering events as nodes and co-reporting as links. Hyperacute cases 18, represented Monotherapy was reported in the majority of cases Pyrexia, diarrhea, fatigue, dyspnea were the most frequently reported symptoms.<\/p>\n

Hyperacute myocarditis was reported in Among fulminant cases, most frequent irAEs were interstitial lung disease , colitis , hypothyroidism , and myocarditis Other co-occurring irAEs were colitis-hepatitis-thyroiditis, and arthritis and psoriasis. Our network approach may complement traditional disproportionality analyses in pharmacovigilance for a more effective signal detection technique, thus supporting regulatory and clinical monitoring, especially in complex scenario such as oncology.<\/p>\n

Target Oncol ; \u2014 Oncologist ; \u2014 Hyperacute toxicity with combination ipilimumab and anti-PD1 immunotherapy. Eur J Cancer ; \u2014 Introduction: The prolongation of the QT interval is a serious and potentially fatal adverse reaction that has led to the discontinuation of many drugs including some opioids. Data mining on pharmacovigilance databases can detect signals that identify early the risk associated with some drugs. Results: A total of drug-reaction pairs was found in opioid reports.<\/p>\n

Analysis of individual opioids show significant signals for QT prolongation for each drug. The temporal evolution of the different signals according to the number of reports included from to shows early significant positivization of signals in the first 6 to 12 months.<\/p>\n

Underlying mechanism is unknown, but it seems to be linked to hERG channel blocking. We propose the evaluation of the trend of change in the confidence intervals of the disproportionality parameters as a measure that can predict the occurrence of clinical events at the population level and a posible usefull strategy to minimize adverse reactions.<\/p>\n

Introduction: Language and speech are increasingly debated as potential markers for diagnosing and monitoring patients with affective and psychotic disorders 1\u20143. However, many neglected factors may confound communicative atypicalities. A comprehensive list of potential confounding drugs will support the design of robust communicative marker studies. Objective: We aim at identifying a list of drugs potentially associated with speech and language disorders, within psychotic and affective disorders.<\/p>\n

Within the FAERS, we considered separately 3 populations psychotic, affective and non-neuropsychiatric disorders , to account for the confounding role of different underlying conditions. Robustness analyses were performed to account for the biases. Results: We identified a list of potential expected and 91 unexpected confounding medications for the identification of communication markers of affective and psychotic disorders e.<\/p>\n

We developed also a MedDRA query proposal for speech and language conditions, formalization of possible biases, and related analyses to account for them. Conclusion: We provided a list of medications to be accounted for in future studies of communicative bio-behavioral markers in affective and psychotic disorders.<\/p>\n

The methodological procedure we developed does not simply facilitate future investigations of communicative biomarkers in other conditions, more crucially it provides a case-study in more rigorous procedures for digital phenotyping in general. Insel TR. Automated assessment of psychiatric disorders using speech: A systematic review. Laryngoscope Investigative Otolaryngology. Voice patterns in schizophrenia: A systematic review and Bayesian meta-analysis. Schizophr Res. Introduction: The comparison of safety profiles for products recently on the market is difficult.<\/p>\n

There is a lack of methodology for quantifying the potential differences between products that have the same indication. Objective: Provide the tools to quantify the differences in spontaneous reporting between two products. An Euclidian distance from the EBGM to the diagonal line measures the deviation from what would have been expected under the null assumption of similar safety profiles. As the deviation does not capture the statistical uncertainty around the estimate, we propose as measure of the deviation the minimal distance of the four Euclidian distances calculated from each of the credibility intervals around the EBGM post Product A and Product B.<\/p>\n

A visualization capturing the global trend of the most substantial differences in reporting was generated. Conclusion: This relatively simple method can provide quantification of the differences in reporting and could help prioritize one product over the other for some population subgroups. Introduction: The application of text mining approaches to identify adverse events AEs from electronic health records EHRs is a growing area of interest in pharmacovigilance research.<\/p>\n

In veterinary medicine, the majority of EHRs consist of unstructured clinical narratives, hence the development of appropriate methods for identifying AEs of interest is an important step in the research process. Identifying renal disease poses a specific challenge as the event may be described in narrative form or implied by reported test results or the use of renal disease specific medications.<\/p>\n

In this study we developed regular expressions regexes to identify relevant mentions of renal disease in veterinary free text clinical narratives. Objective: To develop a method for identifying veterinary patients with renal disease in free text clinical narratives. Methods: Using VeDDRA terminology as a starting point, we used an iterative approach to develop a series of regexes which were then applied to a random sample of 10, clinical narratives.<\/p>\n

In order to measure precision, clinical narratives containing a match to the regexes were reviewed against a case definition by two independent reviewers and disagreement was settled by consensus. Terms in the final regex were derived from three sources\u2014VeDDRA, a word embedding model and expert opinion. To determine recall, the final regex was applied to a sample of consults where the main presenting complaint was deemed to be renal disease by a veterinary clinician.<\/p>\n

Expanding this terminology using a word embedding model improved the PPV to 0. Following changes suggested by a veterinary expert, the PPV of the final regex was improved to 0. When the regex was divided into three components, the PPV for these individual portions was mentions of renal disease 0. When compared against the veterinary clinician validated sample of renal disease consults recall was 0. Conclusion: The developed regex can be used to identify animals with renal disease, with mentions of renal disease treatment being the most specific indicator of clinical disease.<\/p>\n

This method can be employed to filter potential cases of interest from large datasets for use in observational studies. Introduction: We use AI in our everyday lives probably without even realising it. There are many discussions about the use of AI in PV and the potential innovation that it could bring but given the conservative nature of our business and having to work in a highly regulated environment, how can we build confidence to get us over that barrier. Will having the regulators use the same AI make us more comfortable or will legislation be necessary to drive us forward?<\/p>\n

Objective: Explore why PV has lagged behind with AI technology that is commonplace in other parts of our lives and business. Aspects of AI, such as machine learning, are used in areas such as early disease prediction, clinical diagnosis, outcome prediction and prognosis evaluation, personalized treatments, drug discovery, manufacturing, clinical trial research, and more.<\/p>\n

In our personal lives, services like Amazon and Google use AI to understand and target their customers and we accept that as normal. The objective of this presentation is to explore the reluctance of accepting AI in PV and how we can move towards overcoming those obstacles. We will look at some real-life practical examples where AI in PV has worked and what it took to get there.<\/p>\n

Conclusion: We will show that the practical application of AI is achievable and has been achieved in the high volume environment of a regulatory authority. Many of the AI features used by the RA, and the lessons learned from that project, can also be applied in industry, so why are we waiting?<\/p>\n

Introduction: Access to case narratives during signal assessment is crucial to provide a more complete picture of the cases [1], however patient confidentiality needs to be considered. Sharing of narratives while preserving privacy requires de-identification\u2014the removal or replacement of personal identifiers. Automating this task can help with increasing data load. To ensure patient confidentiality throughout the full pharmacovigilance process, the narratives should be de-identified early in the process.<\/p>\n

Person names\u2014one of the more common identifiers in case narratives\u2014can lead to in- direct identification of patients but are challenging to recognise in free text.<\/p>\n

Objective: To develop and evaluate a method for automated de-identification of names in case narratives. Methods: We use an ensemble of BERT [2]\u2014a state-of-the-art language model using deep-neural network\u2014combined with hand-engineered rules for detecting names. Our model is trained on i2b2 deidentification challenge data [3] combined with unprocessed data from the Yellow Card system[4] provided by the MHRA. Because names are rare in the Yellow Card data, the training dataset is prepared using active learning through an independent model.<\/p>\n

Model testing is done on a separate, manually annotated dataset. Evaluation of the deidentification is guided by: 1 how often clinically relevant information is removed and 2 how identifiable the narratives that the model fails to completely de-identify are. We define three categories of identifiability: a Directly identifiable, where subject identification is very likely with the leaked information e.<\/p>\n

Results: Out of the 71 narratives with names and initials, only 12 contained occurrences missed by the system. Manual evaluation found only one directly and one indirectly identifiable narrative due to leaks. It should be noted that the leaked direct identifier was a foreign, non-English name. A single narrative may contain multiple occurrences of names, the table presents results per occurrence. Conclusion: Automated de-identification of names is possible without compromising clinically relevant information.<\/p>\n

Our method can recognise and mask a vast majority of names and most initials while leaving most of the information untouched. Qualitative evaluation shows that the rare leaks that occur tend not to make cases identifiable. Clinical stories are necessary for drug safety. Clin Med. J Biomed Inform. Medicines and Healthcare products Regulatory Agency. The Yellow Card scheme: guidance for healthcare professionals, patients and the public [Internet]. Introduction: Metronidazole is a nitroimidazole antibacterial drug that is mostly used to treat anaerobic bacteria and protozoa infections.<\/p>\n

The adverse side effects of metronidazole include gastrointestinal upset, metallic taste, urticaria, headache, peripheral neuropathy. Metronidazole-induced pancreatitis has been rarely described in the literature so far. Objective: We report a rare case of an acute pancreatitis associated with metronidazole which occurred as a result of a prescription error.<\/p>\n

Methods: This case was reported in February to The National Centre of Pharmacovigilance and evaluated according to the updated French method of causality assessment.<\/p>\n

Results: A year-old male patient with a past medical history of chronic viral hepatitis B treated with entecavir since , presented to the surgery department with an acute onset of a severe epigastric pain radiating through to the back associated with hepatic colic with nausea and vomiting.<\/p>\n

On exam, he had severe epigastric tenderness. Relative negatives in the history included, no lithiasis, no known drug allergies, and no alcohol consumption. Patient symptoms and lipase improved within 3 days after metronidazole withdrawl and initiation of supportive care.<\/p>\n

Conclusion: The likelihood of metronidazole as the incriminating agent was likely in front of a suggestive delay and favorable outcome after the drug withdrawl. It was suggested a the possible dose-response mechanism between metronidazole use and occurrence of pancreatitis, and this case draw attention to the possible acute pancreatitis associated with metronidazole due to a prescription error.<\/p>\n

Metronidazole-associated pancreatitis. Introduction: The possibilities of using current scientific principles to create tools to help give efficiency and help to nurses thereby reducing stress and the potential for errors.<\/p>\n

Also enable patients to maintain independence and less outside contact as technology is used to expand the reach of telehealth. Solutions will be adaptable for independent use by the sight, hearing and mentally challenged. The 1st hurdle is to make it easier for patients and staff to accomplish what they have to do safely and consistently.<\/p>\n

Objective: To simplify the taking of all drugs and supplements using IoT technology. This a paradigm shift from the many efforts to mitigate the challenges of the many aspects of drug delivery. Here medication is always kept in the labelled, legal safety of the original dispensed container until consumed. Safety concerns of pre-pouring will no longer exist. Authentic real-tine medication usage data will be available.<\/p>\n

ISoP and other safety management organizations will be able to execute many tasks with precision. Methods: The innovation is a multi-compartment device that holds a medication container in each compartment. The device has a display that resides in the lid or may be at the front of a drawer type or wall mounted unit. The concept of assigned location forms the basis for these innovations. Stored instructions for many aspects of care and follow-up resides in the device and will be communicated via the display appropriately.<\/p>\n

It can be connected to a larger display, cellphone or other mobile device. Medicine containers are scanned to capture dosing instructions. The assigned location lights up. The container is placed within the compartment and receives an alert at dosing times. The compartment stays lit until the nurse picks up and replaces the container. Video may be activated. Biometric access ensures identity and pill count and time are automatically recorded. Results: Feasibility indicates that the must touch to silent feature is a powerful feature that aids adherence.<\/p>\n

Also the timing methods that ensures safe dosing separation helps to ensure all doses are taken in a given day even if late taking a dose. Relative time rather than time of day dosing is used. Conclusion: Believed to be unsolvable, these discoveries will open the door to the science of individual ingestion by effortlessly notifying and guiding individuals in the consumption and effects of medicines and other items for a safer and healthier life experience.<\/p>\n

Powerful data will be generated for use by ISoP. Introduction: The Summary of Product Characteristics for Ceftriaxone states that as with all beta-lactam antibacterial agents, serious and occasionally fatal hypersensitivity reactions have been reported [1].<\/p>\n

However, the frequency is stated as unknown. Out of 46 reports to Ceftriaxone in the Uganda ADR database, 7 of these are of anaphylactic reactions, and one of them was fatal for the paediatric patient.<\/p>\n

It is not clear in cases of injurious or fatal drug effects who should bear the liability. Objective: To present a case study of a successful legal resolution of a fatal medication error to Ceftriaxone with the involvement of the regulator.<\/p>\n

Methods: This is a retrospective case report. Results: A one-and-a-half-year-old male child was diagnosed with septicaemia with diarrhoea and admitted to a hospital. Day one treatment with Ceftriaxone was stopped due to a reaction of difficulty in breathing. A switch to Ciprofloxacin happened and the patient began to improve.<\/p>\n

Due to a weekend staff shift change, the change to ciprofloxacin was not noted resulting in re-administration of ceftriaxone and anaphylaxis that caused the death of the patient despite all efforts to resuscitate. National Drug Authority performed a causality assessment of the serious adverse event and found that administration of Ceftriaxone was related to the outcome of death. However, it was noted that this was a medication error with no malice aforethought and therefore the health care provider was not liable.<\/p>\n

Publication of these results can aid in encouraging reporting rates among patients and providers. Ceftriaxone 1g Powder for solution for injection. Accessed March 9, General characteristics, economic burden, causative drugs and medical errors associated with medical damage litigation involving severe cutaneous adverse drug reactions in China. Journal of Clinical Pharmacy and Therapeutics.<\/p>\n

Liability associated with prescribing medications. Primary care companion to the Journal of clinical psychiatry. Bhatt AD. Drug-related problems and adverse drug events: negligence, litigation and prevention. The Journal of the Association of Physicians of India. PMID: Physicians’ liability for adverse drug reactions. Southern Medical Journal.<\/p>\n

Introduction: Pharmacotherapeutic Follow-up is a professional practice focused on identification, prevention and resolution of Drug-Related Problems and the causes or errors that originate these problems in patients [1\u20144]. Methods: Clinical pharmacists perform Pharmacotherapeutic Follow-up of hospitalized patients through three evaluations: drug reconciliation, pharmacotherapeutic profile and drug prescription suitability, identifying Drug-Related Problems and medication errors and recording their activities in two databases: the first consists of the evaluation that is carried out weekly and the second corresponds to the pharmaceutical interventions; these bases are validated monthly with each other.<\/p>\n

For this study, data is taken from both databases in the period from June to December and the risk that was reduced by accepted pharmaceutical interventions is calculated. Results: In the review of the database of activities carried out, a progressive increase in the number of evaluations done by clinical pharmacists was observed in drug reconciliation, pharmacotherapeutic profile and drug prescription suitability, identifying discrepancies, medication errors and Problems Related to Medications.<\/p>\n

In the database of pharmaceutical interventions, a significant increase in the risk that was reduced associated with the interventions carried out and accepted was observed; as it can be identified in figure 1, which ranges from Conclusion: The pharmaceutical interventions allowed to improve the prescriptions and with it, identify Problems Related to Medications and medication errors before causing harm to the patient, making the drugs safer.<\/p>\n

Farmacia Hospitalaria, 37 1 , 59\u2014 Introduction: Some side effects of anticholinergic drugs can be relatively harmless such as dry mouth or constipation, but in some cases, they can manifest themselves in the form of heart arrhythmias or as worsening of dementia or delirium.<\/p>\n

The elderly are more prone to show anticholinergic effects, due to a progressive decrease in acetylcholine levels, and are often also treated with drug polytherapy with additive effects which leads to an anticholinergic cognitive burden ACB [1\u20144]. Objective: Verify whether it is possible to identify patients who may experience an adverse reaction due to ACB in real clinical practice through a pharmacological investigation, identify which drugs are the possible cause and re-evaluate the therapy to prevent the onset of adverse reactions.<\/p>\n

Clinical analysis was performed by assigning a score of 1 to each adverse event attributable to ACB in the central nervous system, mouth, eyes, heart, gastrointestinal tract, bladder, and skin. Results: In 34 patients, the total number of drugs prescribed was with an average of 8.<\/p>\n

In these patients, the major drugs responsible for elevated ACB were quetiapine, chlorpromazine, and paroxetine, all three with a value of 3. The 5 patients also showed clinical signs of ACB. Conclusion: Computerized determination of CBA was helpful in preventing adverse reactions, identifying which drugs are responsible for adverse reactions and modifying therapy to avoid the occurrence of adverse events.<\/p>\n

Drug therapy analysis is useful in conjunction with clinical evaluation and can be a valuable tool used in conjunction with tools such as Mini Mental Status. A preliminary study of anticholinergic burden and relationship to a quality of life indicator, engagement in activities, in nursing home residents with dementia.<\/p>\n

J Am Med Dir Assoc. Epub Jan 9. Epub Jun J Am Geriatr Soc. Epub Aug J Nutr Health Aging. Introduction: Presence of a strong medication safety system can prevent many potential medication errors MEs by enforcing safety monitoring on the ordering, prescription, preparation, and administration of medicines [1].<\/p>\n

Furthermore, a well established medication safety system can solve many causes of communication problems which account for over half of all causes associated with medication errors through its electronic based system.<\/p>\n

Unfortunately, many of the existing electronic health records EHRs were designed for purposes of medical billing rather than for medical care, resulting in challenges for using the recorded data for safety data capturing. Moreover, commercially available electronic prescribing and computerized physician order entry systems are cost-prohibitive for many health organization, especially non-profit ones.<\/p>\n

In a previous research project, Egypt Chapter of International Society of Pharmacovigilance ISoP was engaged in developing such system in the hospital of Palestine Red Crescent Society PRCS in Cairo to support identifying MEs that were experienced by refugees through remodeling and adding new features to the existing hospital management system.<\/p>\n

Objective: The objective of this study was to assess the effectiveness of introducing internally low-cost electronic prescription system in reducing the frequency of MEs of different types. Methods: A pre- and post-intervention study was conducted to compare the frequency of MEs before and after replacing the traditionally used paper-based system with an internal electronic-based system in hospital setting.<\/p>\n

MEs were collected by reviewing randomized medical records at base line and after one year of introducing this electronic-based system. More focus was given to medical records of elderly patients and emergency ward. The prescribing errors, transcribing errors, dispensing errors, administration errors were investigated.<\/p>\n

Results: We analyzed paper-based prescriptions at baseline and paper-based and electronic prescriptions at one year of follow-up. The errors were Conclusion: The adoption of internal electronic prescription systems was effective in markedly reducing the frequency of MEs compared to the paper-based system in a low-resource setting where the expense on complex commercial electronic solutions are burden for institutions. Elhawary, M. Drug Saf 45, 97\u201499 Introduction: In spite of its large use, a conspicuous number of paracetamol adverse reaction reports have been recently collected, due to overdosage or posologic mistakes.<\/p>\n

A recent metanalysis by BMC Med Inform Decis Mak [1] has inserted paracetamol in the list of the six drugs causing severe ototoxicity and a pharmacovigilance retrospective study [2] has highlighted that it induced 1. Another recent review on the analgesic standard doses of paracetamol has demonstrated its grade of toxicity, at the maximum prescribed dose [3].<\/p>\n

Methods: A survey of 7 questions on standard dosage, dose adjustment and antidotes to paracetamol overdose was submitted to 36 health professionals nurses, pharmacists, oncologists, hematologists, surgeons in the Cancer Institute of Bari. The answers were collected and charted in diagrams, in order to soon identify critical evidences.<\/p>\n

Conclusion: The collecting data have demonstrated the clinical need to manage accurately old and apparently well-known drugs to grant a controlled clinical risk in hospitals. Pharmacovigilance is a duty for health professionals and the awareness that also old drugs can be causes of toxicity is a substantial starting point for safety of care. Hyunah Shin, Suehyun Lee. Saudi Pharm. Paracetamol: not as safe as we thought? A systematic literature review of observational studies.<\/p>\n

Ann Rheum Dis Mar;75 3 \u20149. Paracetamol: mechanism of action, applications and safety concern. Acta Pol Pharm. Jan\u2014Feb ;71 1 \u2014 Eur J Pain. Introduction: High interest in the last two years was globally put by Health Authorities on the recording, coding, and reporting of medication errors to ensure the safety and effectiveness of the use of medicines and to provide reliable information to healthcare professionals and patients.<\/p>\n

Medical coding is a prerequisite for efficient, effective, and reproducible data outputs. Methods: A sample of medication error coding results was assessed for accuracy and consistency of MedDRA coding and identification of main types of coding errors.<\/p>\n

Results: One-third of the records could not be assessed due to incomplete or unclear verbatims. In one-third, code assignments were correct, but another third of the sample was not adequately coded. Most frequent coding errors corresponded to vague PT assignments, while more detailed information was available for a more precise coding.<\/p>\n

This observation is similar to the EudraVigilance database, where some of the most assigned MedDRA terms for medication errors also represent vague concepts. Conclusion: These findings indicate that understanding of medication error documentation and assessment and of MedDRA content and coding guidelines need to be reinforced. Introduction: Pediatric intoxications represent one of the most common causes of harm to children under the age of six and the fourth leading cause of death in developing countries [1\u20142].<\/p>\n

Data collection and systematic analysis of intoxication cases is of fundamental importance to gain a greater knowledge of toxic domestic, environmental and pharmacological agents [4\u20145]. Gaslini for the period from January to December All poisoning were retrieved from the Hospital Central Database using the International Classification of Disease ICD 9 classification code system, and subsequently entered into a local database for data management.<\/p>\n

Descriptive statistics were undertaken. Our analysis included therefore poisoned patient cases, 70 were from females and 74 from males, with a median age of 3 years old. Out of the total of accesses, Poisoning severity and the need for hospitalization have also been investigated. Conclusion: Implementation of high-performance data collection systems in the Emergency Department could be decisive in guiding clinical choices.<\/p>\n

This study has gathered data on pediatric poisonings in a regional reality in the absence of a Poison Center. Although preliminary, these findings may guide for the improvement of the surveillance system of intoxications in pediatrics. The burden of unintentional injuries among the under-five population in South Asia. Acta Paediatr. Sistema informativo nazionale per la sorveglianza delle esposizioni pericolose e delle intossicazioni: casi rilevati nel Decimo rapporto annuale.<\/p>\n

Surveillance of toxic exposures: the pilot experience of the Poison Control Centers of Milan, Pavia and Bergamo in Ann Ist Super Sanita. Early detection of illness associated with poisonings of public health significance. Ann Emerg Med. Introduction: While electronic health record EHR is a potentially valuable resource of adverse drug reactions ADRs [1,2], these ADRs are frequently not registered, registered in the wrong place or only registered using free-text entry [3,4].<\/p>\n

Free text data cannot be managed and analyzed with mainstream software tools, but this is possible with text mining TM tools.<\/p>\n

Methods: In phase I, the previous rule-based algorithm was translated to a R-algorithm and improved it with the help of previous mentioned issues. Conclusion: The developed R-algorithm identified ADRs, however further research is required to extrapolate the algorithm and to combine it with clinical decision support systems to bring the data back to the physician to increase ADR registration. Data processing and text mining technologies on electronic medical records: A review.<\/p>\n

J Healthc Eng. Text mining applied to electronic medical records: A literature review. Reasons for discontinuation of medication during hospitalization and documentation thereof: a descriptive study of geriatric and internal medicine patients.<\/p>\n

Recurrence of adverse drug reactions following inappropriate re-prescription: Better documentation, availability of information and monitoring are needed. Also know as multicompartment compliance aids, they are devices that allow for medicines to be dispensed into compartments which are separated by days of the week and times of the day.<\/p>\n

Methods: A retrospective analysis was conducted on four hundred and eighty-seven adult patients’ hospital admission episodes. Medications most frequently implicated were antidepressants, ACE inhibitors, analgesics, and antipsychotics. The study highlights that inline with published evidence 5 , the cohort of patients more at risk of DRPs are the older population. Older patients frequently use MDS and are already at risk of DRPs as they frequently have multi-morbidities and polypharmacy 6.<\/p>\n

This study has highlighted that ongoing measures should be considered to reduce DRPs such as deprescribing and regular medication reviews.<\/p>\n

It also highlights the importance of engaging with patients and carers to increase medication education and awareness. Hospitalisations caused by adverse drug reactions ADR : a meta-analysis of observational studies. Pharmacy World and Science. Oswald K. Pill organisers could put older patients at risk of adverse events.<\/p>\n

The Pharmaceutical Journal. Drug safety.<\/p>\n

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